Deadly spiders are accidentally unleashed from a top-secret military installation. Army specialists and Tanks are called in to exterminate the deadly predators, but the outbreak is worse than expected. Weapons of mass destruction have little or no effect on the venomous spiders. Civilians are strangled with spider webs and eaten alive. The Military in a desperate effort to eradicate the killer spiders, decide to demolish the entire city.

With Los Angeles in flaming ruins from a nuclear attack, solders mop up what is left of the deadly spider with a giant spider killing robot: Mecha-Destructor. Unfortunately, a terrorist escaped from the weapons base with a suit case full of the creatures. Shot down behind the Beluxor Hotel, the spiders make their way in the pyramid and up and down the strip devouring gamblers, show girls and destroying many landmarks.