An ordinary man makes an extraordinary discovery when a train accident leaves his fellow passengers dead — and him unscathed. The answer to this mystery could lie with the mysterious Elijah Price, a man who suffers from a disease that renders his bones as fragile as glass.

Though Kevin has evidenced 23 personalities to his trusted psychiatrist, Dr. Fletcher, there remains one still submerged who is set to materialize and dominate all the others. Compelled to abduct three teenage girls led by the willful, observant Casey, Kevin reaches a war for survival among all of those contained within him — as well as everyone around him — as the walls between his compartments shatter apart.

In a series of escalating encounters, former security guard David Dunn uses his supernatural abilities to track Kevin Wendell Crumb, a disturbed man who has twenty-four personalities. Meanwhile, the shadowy presence of Elijah Price emerges as an orchestrator who holds secrets critical to both men.