James Marsden
Diggs (voice)
Nick Nolte
Butch (voice)
Christina Applegate
Catherine (voice)
Bette Midler
Kitty Galore (voice)
Pascale Hutton
Jackie
Katt Williams
Seamus (voice)
Neil Patrick Harris
Lou (voice)
Sean Hayes
Mr. Tinkles (voice)
Wallace Shawn
Calico (voice)
Roger Moore
Tab Lazenby (voice)
Joe Pantoliano
Peek (voice)
Michael Clarke Duncan
Sam (voice)
Chris O'Donnell
Shane
Jack McBrayer
Chuck
Fred Armisen
Freidrich
Kiernan Shipka
Little Girl
Paul Rodríguez
Crazy Carlito (voice)
J.K. Simmons
Gruff K-9 (voice)
Grey DeLisle
Security Bulldog/Catherine's Niece/Cat Spy Analyst
E. G. Daily
Scrumptious / Patches / Catherine's Niece (voice)
Phil LaMarr
Paws / Cat Spy Analyst (voice)
Michael Beattie
Angus MacDougall (voice)
Jeff Bennett
Duncan MacDougall (voice)
Malcolm Stewart
Captain Flemming
Dawn Chubai
Reporter
Keith Dallas
Coit Tower Guard
Len Morganti
Rex (voice)
Betty Phillips
Cat Lady
Christopher Lee Parson
Hep Cat / Cat Spy Analyst (voice)
Bumper Robinson
Cool Cat / Dog Killa / Cat Spy Analyst / Slim (voice)
Rick D. Wasserman
Rocky (voice)
Roger L. Jackson
Inmate Fat Cat (voice)
Bonnie Cahoon
Dog HQ PA / Catherine's Niece (voice)
André Sogliuzzo
Snobby K-9 (voice)
Carlos Alazraqui
Cat Gunner / Cat Spy Analyst (voice)
Grey DeLisle
Security Bulldog / Catherine's Niece / Cat Spy Analyst (voice)
Ingrid Tesch
Mom
Amitai Marmorstein
Playland Worker
Robert Hewko
Old Man
Mark Burgess
Used Car Salesman
Sage Brocklebank
Park Patron
Brad Peyton
Director
Ron J. Friedman
Writer
Steve Bencich
Writer
Sue Houston Safianoff
Animation
Andy Hass
Animation
Seung Hoo Ihm
Animation
Jeremy Stewart
Animation
Polly Johnsen
Producer
Andrew Lazar
Producer
Greg Michael
Second Unit Director
Glenn Ficarra
Characters
John Requa
Characters
Ramsey Avery
Art Direction
Bruce Berman
Executive Producer
Brent O'Connor
Executive Producer
Miri Yoon
Co-Producer
Christopher Lennertz
Original Music Composer
Steven Poster
Director of Photography
Julie Rogers
Editor
Rusty Smith
Production Design
Tish Monaghan
Costume Design
Carol Lavallee
Set Decoration
Nate Fredenburg
Art Direction
Sandi Tanaka
Art Direction
Ray McIntyre Jr.
Stereoscopic Supervisor
Q Fortier
Visual Effects
Mo Henry
Negative Cutter